The world of cannabinoids: much more than just THC & CBD
THC and CBD are well-known, but the cannabis plant contains dozens of other cannabinoids that are just as fascinating. In this blog post, you'll discover what they are, how they differ, and why their potential is far from exhausted.
What exactly are cannabinoids?
Cannabinoids are bioactive compounds found in the cannabis plant ( phytocannabinoids ) and in the human body ( endocannabinoids ). To date, over 100 phytocannabinoids have been identified. Together with terpenes and flavonoids, they define the plant's complete chemical profile.
At House Jane, we work with a wide range of legal, plant-based cannabinoids such as CBD, CBG, CBN, and CBDA. These compounds are being studied by universities and research institutions worldwide.
How do cannabinoids work?
In the body, cannabinoids interact with the endocannabinoid system (ECS) , a natural network of receptors including CB1 and CB2. These function as "switches" in numerous biological processes.
Many phytocannabinoids interact with this network: sometimes directly with receptors, sometimes via other pathways that influence the availability of endogenous substances. This allows neurotransmitter signaling to be indirectly controlled.
For example, CBD doesn't bind directly to CB1/CB2, but rather works indirectly and can also interact with other receptors such as 5-HT1A (serotonin) and TRPV channels. This is for informational purposes only, not a medical claim.
Known cannabinoids at House Jane
The most researched compound. CBD primarily influences the ECS indirectly and also interacts with 5-HT1A and TRPV channels, among others. It's often discussed in contexts like stress and sleep; it's not a recognized medicine without a doctor/pharmacist.
Often the "parent molecule" in the biosynthesis of other cannabinoids. Mentioned in the literature in relation to receptors involved in inflammatory processes and neuronal signaling pathways.
Produced by the oxidation of THC. Less extensively researched; anecdotally often associated with relaxation and appetite. Not a recognized sleep aid.
The sour, raw form of CBD. Known from studies on enzyme pathways (such as COX-2) and a complementary profile to CBD. Interesting in raw extracts.
What is the difference between Full Spectrum, Broad Spectrum, and Isolate?
Full Spectrum
Complete plant profile (cannabinoids, terpenes, flavonoids). This allows the entourage effect to play a role: compounds in context.
Broad Spectrum
Full spectrum with specific components (e.g., THC) removed. For those who want to avoid certain ingredients.
Isolate
Single compound (e.g. pure CBD) in carrier oil. Neutral profile, without entourage context.
Why does House Jane choose a broad spectrum of cannabinoids?
- Scientific value: we focus on connections that are being structurally investigated.
- User experience: feedback from customers and healthcare professionals is taken into account in our product range.
- Legislation: All our products are legal in Belgium and traceable according to high standards.
We work exclusively with partners who share our vision – like pioneers like De Herborist . Quality, transparency, and expertise are our foundation.